Inhibition of Some Virulence Factors in Candida albicans by Bioemulsifier Purified from Saccharomyces cerevisiae
Keywords:
Bioemulsifier, Saccharomyces cerevisiae, Candida albicansAbstract
As viable alternatives to some synthetic surfactants, biosurfactants, which are amphiphilic compounds, are gaining more and more interest from the scientific community. Therefore, Saccharomyces cerevisiae was used to create biosurfactant as a bioemulsifier at different levels. The best producer isolate was selected for biosurfactant extraction by boiling, acetone precipitation, and chromatographic techniques on sephadex G-75, resulting in a final recovery of 55%. Candida albicans was identified as the primary pathogen responsible for vulvovaginitis. Certain virulence factors, including the synthesis of phospholipase, haemolysin, and the hyphal transition, were inhibited by the pure biosurfactant for control of the increasing infections caused by Candida albicans.
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