Inhibition Biofilm Producer Candida albicans Causing Thrust Candidiasis by Purified Invertase from Saccharomyces Cerevisiae
Keywords:
Candida albicans, invertase, Saccharomyces cerevisiaeAbstract
In invasive oral candidiasis, a serious health issue in developing countries, Candida albicans is the most often isolated species. Thus, invertase was isolated from Saccharomyces cerevisiae, refined using acetone as an organic solvent, and then highly recovered by chromatographic techniques. One of the main manufacturers of biofilm is Candida albicans, which is the cause of oral candidiasis. After 72 hours of incubation, the percentage of biofilm inhibition reached a range of 78–89%. This indicates that invertase has a growing inhibitory impact on Candida biofilm development when concentration and incubation period are increased. Thus, the potential use of invertase as an antibiofilm agent against multi-drug resistance Candida albicans.
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